June 30, 2006, Newsletter Issue #22: The Bextra debate

Tip of the Week

One criticism of Bextra is that is was only available in 10 mg doses. Some studies suggest that this is an unnecessarily large dose. In a review article of ten large, well-controlled, randomized trials of Bextra, doses of 2.5 and 5 mg/day were significantly superior to placebo for osteoarthritis of the knee. 5 mg of Bextra was effective for osteoarthritis of the hip. Your doctor is unlikely to know any of this, because it isn't mentioned in the Bextra package insert or Physicians' Desk Reference.

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