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Both Vioxx and Bextra have been taken off the market, leaving arthritis patients confused about how to safely get effective pain relief while protecting their hearts and stomachs. According to a new study, the majority of arthritis patients may be advised to use a combination of two drugs - a non-COX-2 pain reliever like Aleve, Advil or Motrin and a gastro-protective medicine like Prilosec or Nexium. Some experts believe this drug combination may have always been the best solution.